Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model.

ABSTRACT:

Context

Cryptotanshinone (CT), a lipophilic compound extracted from roots of Salvia miltiorrhiza Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis. Our previous findings suggest that CT plays a protective role in cerebral stroke. However, the molecular mechanisms underlying CT protection in ischaemic stroke remain unclear.

Objective

This study examines the effect of CT on ischaemic stroke.

Materials and methods

We used the middle cerebral artery occlusion (MCAO) rat (Sprague-Dawley rats, 200 ± 20 g, n = 5) model with a sham operation group was treated as negative control. MCAO rats were treated with 15 mg/kg CT using intragastric administration. Moreover, TGF-β (5 ng/mL) was used

SUBMITTER: Zhu F 

PROVIDER: S-EPMC8871624 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature