The PI3K/AKT Pathway and PTEN Gene Are Involved in "Tree-Top Disease" of Lymantria dispar.

ABSTRACT: Nucleopolyhedrovirus (NPV) can alter its host behaviour such that infected larvae hang at the top of trees before their death. This phenomenon was firstly described by Hofmann in 1891 and named as "tree-top disease". Subsequent studies have described effects during the infection proceedings as NPVs manipulate the host to avoid the immune response, cross defensive barriers and regulate hormones. In this study, we demonstrate that the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway is involved in host manipulation by Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV). Particularly at the late stage of infection, a multifunctional dephosphorylase in the PI3K/AKT signaling pathway is dynamically upregulated, namely, the phosphatidylinositol-3, 4, 5-trisphosphate 3-phos

SUBMITTER: Li F 

PROVIDER: S-EPMC8871656 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature