The Frontal and Cerebellar Metabolism Related to Cognitive Dysfunction in Multiple System Atrophy.

ABSTRACT:

Background

Cognitive dysfunctions have been reported in multiple system atrophy (MSA). However the underlying mechanisms remain to be elucidated. This study aimed to explore the possible cerebral metabolism associated with domain-specific cognitive performances in MSA.

Methods

A total of 84 patients were diagnosed as probable or possible MSA, comprised of 27 patients as MSA with predominant parkinsonism (MSA-P) and 57 patients as MSA with predominant cerebellar ataxia (MSA-C). The comprehensive neuropsychological tests and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) imaging were performed. Z-score was calculated to non-dimensionalize and unify indicators of different tests in the domains of executive function, attention, l

SUBMITTER: Shen C 

PROVIDER: S-EPMC8871713 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature