Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review.

ABSTRACT: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy. It is also increasingly used off-label in the neonatal intensive care unit. Despite the frequent use of paracetamol, concerns have been raised regarding the high variability in neonatal dosing regimens and the long-term safety of early life exposure. To investigate the available evidence on the long-term safety of prenatal and neonatal paracetamol exposure. We conducted a systematic search of the electronic databases Ovid Medline, Ovid Embase and Web of Science from inception to August 2021 for original research studies of any design that described the use of paracetamol in the prenatal or neonatal (within the first four weeks of life) periods and examined the occurrence of neurodevelopmental, atopic or reproduct

SUBMITTER: Patel R 

PROVIDER: S-EPMC8871754 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature