Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection.

ABSTRACT: MicroRNAs (miRNAs) are crucial regulators of cellular processes, including metabolism. Attempts to use miRNAs as therapeutic agents are being explored in several areas, including the control of cancer progression. Recent evidence suggests fine tuning miRNA activity to reprogram tumor cell metabolism has enormous potential as an alternative treatment option. Indeed, cancer growth is known to be linked to profound metabolic changes. Likewise, the emerging field of immunometabolism is leading to a refined understanding of how immune cell proliferation and function is governed by glucose homeostasis. Different immune cell types are now known to have unique metabolic signatures that switch in response to a changing environment. T-cell subsets exhibit distinct metabolic profiles which underlie t

SUBMITTER: Gibson MS 

PROVIDER: S-EPMC8872267 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature