Subcellular Dynamics of a Conserved Bacterial Polar Scaffold Protein.

ABSTRACT: In order to survive, bacterial cells rely on precise spatiotemporal organization and coordination of essential processes such as cell growth, chromosome segregation, and cell division. Given the general lack of organelles, most bacteria are forced to depend on alternative localization mechanisms, such as, for example, geometrical cues. DivIVA proteins are widely distributed in mainly Gram-positive bacteria and were shown to bind the membrane, typically in regions of strong negative curvature, such as the cell poles and division septa. Here, they have been shown to be involved in a multitude of processes: from apical cell growth and chromosome segregation in actinobacteria to sporulation and inhibition of division re-initiation in firmicutes. Structural analyses revealed that DivIVA protein

SUBMITTER: Giacomelli G 

PROVIDER: S-EPMC8872289 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature