Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells.

ABSTRACT:

Background

Lung cancer in men and women is considered the leading cause for cancer-related mortality worldwide. Anti-cancer peptides represent a potential untapped reservoir of effective cancer therapy.

Methodology

Box-Behnken response surface design was applied for formulating Alendronate sodium (ALS)-mastoparan peptide (MP) nanoconjugates using Design-Expert software. The optimization process aimed at minimizing the size of the prepared ALS-MP nanoconjugates. ALS-MP nanoconjugates' particle size, encapsulation efficiency and the release profile were determined. Cytotoxicity, cell cycle, annexin V staining and caspase 3 analyses on A549 cells were carried out for the optimized formula.

Results

The results revealed that the optimized formula was of 134.91±5.1 nm parti

SUBMITTER: Alhakamy NA 

PROVIDER: S-EPMC8872391 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature