Identification of HIV Rapid Mutations Using Differences in Nucleotide Distribution over Time.

ABSTRACT: Mutation is the driving force of species evolution, which may change the genetic information of organisms and obtain selective competitive advantages to adapt to environmental changes. It may change the structure or function of translated proteins, and cause abnormal cell operation, a variety of diseases and even cancer. Therefore, it is particularly important to identify gene regions with high mutations. Mutations will cause changes in nucleotide distribution, which can be characterized by natural vectors globally. Based on natural vectors, we propose a mathematical formula for measuring the difference in nucleotide distribution over time to investigate the mutations of human immunodeficiency virus. The studied dataset is from public databases and includes gene sequences from twenty HIV-i

SUBMITTER: Sun N 

PROVIDER: S-EPMC8872422 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature