The m⁶A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay.

ABSTRACT: The role of N6-methyladenosine (m⁶A) modifications has increasingly been associated with a diverse set of roles in modulating viruses and influencing the outcomes of viral infection. Here, we report that the landscape of m⁶A deposition is drastically shifted during Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection for both viral and host transcripts. In line with previous reports, we also saw an overall decrease in host methylation in favor of viral messenger RNA (mRNA), along with 5' hypomethylation and 3' hypermethylation. During KSHV lytic infection, a major shift in overall mRNA abundance is driven by the viral endoribonuclease SOX, which induces the decay of greater than 70% of transcripts. Here, we reveal that interlukin-6 (IL-6) mRNA, a well-charac

SUBMITTER: Macveigh-Fierro D 

PROVIDER: S-EPMC8872733 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature