Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection.

ABSTRACT: Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies, and have been successfully employed for the treatment of viral diseases. Humans express 12 IFN-alpha (α) subtypes, which activate downstream signaling cascades and result in distinct patterns of immune responses and differential antiviral responses. Inborn errors in IFN-I immunity and the presence of anti-IFN autoantibodies account for very severe courses of COVID-19; therefore, early administration of IFN-I may be protective against life-threatening disease. Here we comprehensively analyzed the antiviral activity of all IFNα subtypes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to identify the underlying immune signatu

SUBMITTER: Schuhenn J 

PROVIDER: S-EPMC8872780 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature