Background-suppressed tumor-targeted photoacoustic imaging using bacterial carriers.

ABSTRACT: Photoacoustic (PA) imaging offers promise for biomedical applications due to its ability to image deep within biological tissues while providing detailed molecular information; however, its detection sensitivity is limited by high background signals that arise from endogenous chromophores. Genetic reporter proteins with photoswitchable properties enable the removal of background signals through the subtraction of PA images for each light-absorbing form. Unfortunately, the application of photoswitchable chromoproteins for tumor-targeted imaging has been hampered by the lack of an effective targeted delivery scheme; that is, photoswitchable probes must be delivered in vivo with high targeting efficiency and specificity. To overcome this limitation, we have developed a tumor-targeting deliver

SUBMITTER: Gao R 

PROVIDER: S-EPMC8872805 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature