Controlling for Variable Transposition Rate with an Age-Adjusted Site Frequency Spectrum.

ABSTRACT: Recognition of the important role of transposable elements (TEs) in eukaryotic genomes quickly led to a burgeoning literature modeling and estimating the effects of selection on TEs. Much of the empirical work on selection has focused on analyzing the site frequency spectrum (SFS) of TEs. But TE evolution differs from standard models in a number of ways that can impact the power and interpretation of the SFS. For example, rather than mutating under a clock-like model, transposition often occurs in bursts which can inflate particular frequency categories compared with expectations under a standard neutral model. If a TE burst has been recent, the excess of low-frequency polymorphisms can mimic the effect of purifying selection. Here, we investigate how transposition bursts affect the freque

SUBMITTER: Horvath R 

PROVIDER: S-EPMC8872973 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature