The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium.

ABSTRACT:

Background

The incidence of endometrial cancer is rising in parallel with the obesity epidemic. Obesity increases endometrial cancer risk and weight loss is protective, but the underlying mechanisms are incompletely understood. We hypothesise that the immune microenvironment may influence susceptibility to malignant transformation in the endometrium. The aim of this study was to measure the impact of obesity and weight loss on the immunological landscape of the endometrium.

Methods

We conducted a prospective cohort study of women with class III obesity (body mass index, BMI ≥ 40 kg/m²) undergoing bariatric surgery or medically-supervised low-calorie diet. We collected blood and endometrial samples at baseline, and two and 12 months after weight loss intervention.

SUBMITTER: Naqvi A 

PROVIDER: S-EPMC8872994 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature