A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.

ABSTRACT: Depression constitutes a leading cause of disability worldwide. Despite extensive research on its interaction with psychobiological factors, associated pathways are far from being elucidated. Metabolomics, assessing the final products of complex biochemical reactions, has emerged as a valuable tool for exploring molecular pathways. We conducted a metabolome-wide association analysis to investigate the link between the serum metabolome and depressed mood (DM) in 1411 participants of the KORA (Cooperative Health Research in the Augsburg Region) F4 study (discovery cohort). Serum metabolomics data comprised 353 unique metabolites measured by Metabolon. We identified 72 (5.1%) KORA participants with DM. Linear regression tests were conducted modeling each metabolite value by DM status, adjuste

SUBMITTER: Zacharias HU 

PROVIDER: S-EPMC8873015 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature