Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

ABSTRACT: Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly heterogeneous abnormalities in functional brain connectivity. However, the origin and significance of this phenomenon remain unclear. To unravel ASD connectopathy and relate it to underlying etiological heterogeneity, we carried out a bi-center cross-etiological investigation of fMRI-based connectivity in the mouse, in which specific ASD-relevant mutations can be isolated and modeled minimizing environmental contributions. By performing brain-wide connectivity mapping across 16 mouse mutants, we show that different ASD-associated etiologies cause a broad spectrum of connectional abnormalities in which diverse, often diverging, connectivity signatures are recognizable. Despite this heterogeneity, the identified conne

SUBMITTER: Zerbi V 

PROVIDER: S-EPMC8873017 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature