Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing.

ABSTRACT: Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties. Feeder cells induce activation and proliferation of NK cells via cell surface receptor-ligand interactions, supported by cytokines. Feeder cell expanded NK cell products have supported several NK cell adoptive transfer clinical trials over the past decade. Genome engineered NK cell therapies, including CAR-NK cells, seek to combine innate and alloreactive NK cell anti-tumor activity with antigen specific targeting or additional modifications aimed at improving NK cell persistence, homing or effector function. The profound activating and expansion stimulus provided by feeder cells is integral to current applications of c

SUBMITTER: Gurney M 

PROVIDER: S-EPMC8873083 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature