A Simplified Plasticity Model Based on Synaptic Tagging and Capture Theory: Simplified STC.

ABSTRACT: The formation and consolidation of memory play a vital role for survival in an ever-changing environment. In the brain, the change and stabilization of potentiated and depressed synapses are the neural basis of memory formation and maintenance. These changes can be induced by rather short stimuli (only a few seconds or even less) but should then be stable for months or years. Recently, the neural mechanism of conversion from rapid change during the early phase of synaptic plasticity into a stable memory trace in the late phase of synaptic plasticity is more and more clear at the protein and molecular levels, among which synaptic tagging and capture (STC) theory is one of the most popular theories. According to the STC theory, the change and stabilization of synaptic efficiency mainly depen

SUBMITTER: Ding Y 

PROVIDER: S-EPMC8873158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature