Programmed Cell Death and Autophagy in an in vitro Model of Spontaneous Neuroretinal Degeneration.

ABSTRACT: Retinal neurodegenerative diseases are the leading causes of visual impairment and irreversible blindness worldwide. Although the retinal response to injury remains closely similar between different retinal neurodegenerative diseases, available therapeutic alternatives are only palliative, too expensive, or very specific, such as gene therapy. In that sense, the development of broad-spectrum neuroprotective therapies seems to be an excellent option. In this regard, it is essential to identify molecular targets involved in retinal degeneration, such as cell death mechanisms. Apoptosis has been considered as the primary cell death mechanism during retinal degeneration; however, recent studies have demonstrated that the only use of anti-apoptotic drugs is not enough to confer good neuroprotec

SUBMITTER: Puertas-Neyra K 

PROVIDER: S-EPMC8873173 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature