Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal.

ABSTRACT: The adaptive immune system is critical to an effective response to infection in vertebrates, with T-helper (Th) cells pivotal in orchestrating these responses. In natural populations where co-infections are the norm, different Th responses are likely to play an important role in maintaining host health and fitness, a relationship which remains poorly understood in wild animals. In this study, we characterised variation in functionally distinct Th responses in a wild population of Soay sheep by enumerating cells expressing Th-subset specific transcription factors and quantifying Th-associated cytokines. We tested the prediction that raised Th1 and Th2 responses should predict reduced apicomplexan and helminth parasite burdens, respectively. All measures of Th-associated cytokine production

SUBMITTER: Corripio-Miyar Y 

PROVIDER: S-EPMC8873199 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature