Chip-based multimodal super-resolution microscopy for histological investigations of cryopreserved tissue sections.

ABSTRACT: Histology involves the observation of structural features in tissues using a microscope. While diffraction-limited optical microscopes are commonly used in histological investigations, their resolving capabilities are insufficient to visualize details at subcellular level. Although a novel set of super-resolution optical microscopy techniques can fulfill the resolution demands in such cases, the system complexity, high operating cost, lack of multi-modality, and low-throughput imaging of these methods limit their wide adoption for histological analysis. In this study, we introduce the photonic chip as a feasible high-throughput microscopy platform for super-resolution imaging of histological samples. Using cryopreserved ultrathin tissue sections of human placenta, mouse kidney, pig heart,

SUBMITTER: Villegas-Hernandez LE 

PROVIDER: S-EPMC8873254 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature