The impact of tethered recording techniques on activity and sleep patterns in rats.

ABSTRACT: Electrophysiological recordings in animals constitute frequently applied techniques to study neuronal function. In this context, several authors described tethered recordings as a semi-restraint situation with negative implications for animal welfare and suggested radiotelemetric setups as a refinement measure. Thus, we here investigated the hypothesis that tethered recordings exert measurable effects on behavioral and sleep patterns in Sprague-Dawley rats. Animals were kept in monitoring glass cages either with or without a head connection to a recording cable. Saccharin preference, nest building, serum corticosterone and fecal corticosterone metabolite levels were in a comparable range in both groups. The proportion of vigilance states was not affected by the cable connection. Minor grou

SUBMITTER: Aulehner K 

PROVIDER: S-EPMC8873297 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature