Potential value of lncRNAs as a biomarker for proliferative diabetic retinopathy.

ABSTRACT:

Objectives

To investigate the differences in lncRNAs expression in whole blood between diabetic retinopathy (DR) patients and healthy subjects, and to evaluate the potential value of lncRNAs as a diagnostic biomarker for proliferative diabetic retinopathy (PDR).

Methods

A series of 34 PDR patients, 34 patients with non-proliferative DR (NPDR) and 34 healthy participants were enroled. Differentially expressed lncRNAs were demonstrated using high-throughput sequencing and validated using qRT-PCR. Gene Ontology (GO) was performed to explore the possible biological function of the differentially expressed lncRNAs. lncRNA/mRNA coexpression network was built to determine the targets of differentially expressed lncRNAs. Receiver operating characteristic (ROC) analysis was utilized

SUBMITTER: Liu B 

PROVIDER: S-EPMC8873401 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature