Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability.

ABSTRACT: Haemophilus influenzae is an opportunistic pathogen adapted to the human respiratory tract. Non-typeable H. influenzae are highly heterogeneous, but few studies have analysed the genomic variability of capsulated strains. This study aims to examine the genetic diversity of 37 serotype f isolates from the Netherlands, Portugal, and Spain, and to compare all capsulated genomes available on public databases. Serotype f isolates belonged to CC124 and shared few single nucleotide polymorphisms (SNPs) (n = 10,999), but a high core genome (> 80%). Three main clades were identified by the presence of 75, 60 and 41 exclusive genes for each clade, respectively. Multi-locus sequence type analysis of all capsulated genomes revealed a reduced number of clonal complexes associated with each serotype. Pa

SUBMITTER: Gonzalez-Diaz A 

PROVIDER: S-EPMC8873416 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature