Sex-specific differences in KCC2 localisation and inhibitory synaptic transmission in the rat hippocampus.

ABSTRACT: Sexual differentiation of the brain is influenced by testosterone and its metabolites during the perinatal period, when many aspects of brain development, including the maturation of GABAergic transmission, occur. Whether and how testosterone signaling during the perinatal period affects GABAergic transmission is unclear. Here, we analyzed GABAergic circuit functional markers in male, female, testosterone-treated female, and testosterone-insensitive male rats after the first postnatal week and in young adults. In the hippocampus, mRNA levels of proteins associated with GABA signaling were not significantly affected at postnatal day (P) 7 or P40. Conversely, membrane protein levels of KCC2, which are critical for determining inhibition strength, were significantly higher in females compared

SUBMITTER: Wolf DC 

PROVIDER: S-EPMC8873453 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature