Ontology highlight
ABSTRACT:
SUBMITTER: Pradipta AR
PROVIDER: S-EPMC8873552 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Chemical science 20210401 15
Cytotoxic anticancer drugs used in chemotherapy are often antiproliferative agents that preferentially kill rapidly growing cancer cells. Their mechanism relies mainly on the enhanced proliferation rate of cancer cells and is not genuinely selective for cancer cells. Therefore, these drugs can also significantly affect healthy cells. Prodrug therapy provides an alternative approach using a less cytotoxic form of anticancer drug. It involves the synthesis of inactive drug derivatives which are co ...[more]