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Targeting TNF-α for COVID-19: Recent Advanced and Controversies.

ABSTRACT: Recent advances in the pathophysiologic understanding of coronavirus disease 2019 (COVID-19) suggests that cytokine release syndrome (CRS) has an association with the severity of disease, which is characterized by increased tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-2, IL-7, and IL-10. Hence, managing CRS has been recommended for rescuing severe COVID-19 patients. TNF-α, one of the pro-inflammatory cytokines commonly upregulated in acute lung injury, triggers CRS and facilitates SARS-CoV-2 interaction with angiotensin-converting enzyme 2 (ACE2). TNF-α inhibitors, therefore, may serve as an effective therapeutic strategy for attenuating disease progression in severe SARS-CoV-2 infection. Below, we review the possibilities and challenges of targeting the TNF-α pathway in COVID-19 treatment.

SUBMITTER: Guo Y

PROVIDER: S-EPMC8873570 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Targeting TNF-α for COVID-19: Recent Advanced and Controversies.

Guo Yi Y Hu Ke K Li Yuxuan Y Lu Chanjun C Ling Ken K Cai Chuanqi C Wang Weici W Ye Dawei D

Frontiers in public health 20220211

Recent advances in the pathophysiologic understanding of coronavirus disease 2019 (COVID-19) suggests that cytokine release syndrome (CRS) has an association with the severity of disease, which is characterized by increased tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-2, IL-7, and IL-10. Hence, managing CRS has been recommended for rescuing severe COVID-19 patients. TNF-α, one of the pro-inflammatory cytokines commonly upregulated in acute lung injury, triggers CRS and facilitates SAR ...[more]

PMID: 35223745

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