Opportunity of Next-Generation Sequencing-Based Short Tandem Repeat System for Tumor Source Identification.

ABSTRACT: Personal identification using the tumor DNA not only plays an important role in postoperative tissue management but also might be the only accessible source of biological material in forensic identification. Short tandem repeat (STR) is the worldwide accepted forensic marker; however, widespread loss of heterozygosity (L) in tumor tissues challenges the personal identification using the conventional capillary electrophoresis (CE)-based STR typing system (CE-STR). Because the tumors are mixtures of tumor cells and basal cells, we inferred that every germline-originated allele should be detected if the detection method was sensitive enough. Next-generation sequencing (NGS) is known as a highly sensitive application, which might be a promising tool for tumor source identification. In the stud

SUBMITTER: Chen A 

PROVIDER: S-EPMC8873583 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature