Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation.

ABSTRACT: The phenotypic plasticity in responses to short-term stress can provide clues for understanding the adaptive fixation mechanism of genetic variation during long-term exposure to extreme environments. However, few studies have compared short-term stress responses with long-term evolutionary patterns; in particular, no interactions between the two processes have been evaluated in high-altitude environment. We performed RNA sequencing in embryo fibroblasts derived from great tits and mice to explore transcriptional responses after exposure to simulated high-altitude environmental stresses. Transcriptional changes of genes associated with metabolic pathways were identified in both bird and mice cells after short-term stress responses. Genomic comparisons among long-term highland tits and mamma

SUBMITTER: Chen X 

PROVIDER: S-EPMC8873613 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature