Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery.

ABSTRACT:

Purpose

The characteristic of pulsed beam delivery for synchrotron-based carbon-ion radiotherapy has led to the emergence of many scanning scenarios in order to improve the treatment efficiency and accuracy of moving target volume. Here, we aim to evaluate a novel breathing guidance motion mitigation performance under different synchrotron flattop operation modes in carbon-ion radiotherapy.

Methods

With the use of twelve 4DCT datasets of lung cancer patients who had been treated with respiratory-gated carbon-ion pencil beam therapy, range-adapted internal target volume (raITV) plans were optimized. Under the fixed flattop with single-energy and extended flattop with multi-energy synchrotron operation modes, the 4D treatments with breathing guidance and free breathing-based g

SUBMITTER: He P 

PROVIDER: S-EPMC8873937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature