Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs.

ABSTRACT: In this work, we highlight an electrophysiological feature often observed in recordings from mouse CA1 pyramidal cells that has so far been ignored by experimentalists and modelers. It consists of a large and dynamic increase in the depolarization baseline (i.e., the minimum value of the membrane potential between successive action potentials during a sustained input) in response to strong somatic current injections. Such an increase can directly affect neurotransmitter release properties and, more generally, the efficacy of synaptic transmission. However, it cannot be explained by any currently available conductance-based computational model. Here we present a model addressing this issue, demonstrating that experimental recordings can be reproduced by assuming that an input current modifi

SUBMITTER: Bianchi D 

PROVIDER: S-EPMC8873947 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature