Modelling the effects of variability in feeding rate on growth - a vital step for DEB-TKTD modelling.

ABSTRACT: A major limitation of dietary toxicity studies on rodents is that food consumption often differs between treatments. The control treatment serves as a reference of how animals would have grown if not for the toxicant in their diet, but this comparison unavoidably conflates the effects of toxicity and feeding rate on body weight over time. A key advantage of toxicity models based on dynamic energy budget theory (DEB) is that chemical stress and food consumption are separate model inputs, so their effects on growth rate can be separated. To reduce data requirements, DEB convention is to derive a simplified feeding input, f, from food availability; its value ranges from zero (starvation) to one (food available ad libitum). Observed food consumption in dietary toxicity studies shows that, even

SUBMITTER: Martin T 

PROVIDER: S-EPMC8873987 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature