Positive Cofactor 4 as a Potential Radiation Biodosimeter for Early Assessment.

ABSTRACT: During a major radiation event, a large number of people need to be rapidly assessed for radiation damage to ensure effective medical treatment and efficient use of medical resources. However, current techniques cannot meet the requirement of rapid detection of large quantities of samples in an emergency. It is essential to develop rapid and accurate radiation biodosimeters in peripheral blood. Here, we identified radiation sensitive genes in mice by RNA sequencing and evaluated their utility as radiation biodosimeters in human cell lines. Mice were subjected to gamma-irradiation with different doses (0-8 Gy, .85 Gy/min), and the tail venous blood was analyzed by RNA sequencing. We have identified 5 genes with significantly differential expression after radiation exposure. We found that po

SUBMITTER: Ma L 

PROVIDER: S-EPMC8874181 | biostudies-literature | 2022 Jan-Mar

REPOSITORIES: biostudies-literature