Angled Insertion of Microneedles for Targeted Antigen Delivery to the Epidermis.

ABSTRACT: Peanut and tree nut allergies account for most food-induced anaphylactic events. The standard allergy immunotherapy approach involves subcutaneous injection, which is challenging because severe adverse reactions can occur when antigens spread systemically. Allergen localization within the epidermis (i.e., the upper 20-100 µm of skin) should significantly reduce systemic uptake, because the epidermis is avascular. Microneedle (MN) patches provide a convenient method for drug delivery to the skin, but they generally target both epidermis and dermis, leading to systemic delivery. In this study, we adapted MN technology for epidermal localization by performing angled insertion of 250 µm-long MNs that limits MN insertion depth mostly to the epidermis. We designed a biplanar insertion device to

SUBMITTER: Murty R 

PROVIDER: S-EPMC8874562 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature