Disregarded Measurement Uncertainty Contributions and Their Magnitude in Measuring Plasma Glucose.

ABSTRACT:

Background

Each measurement is subject to measurement uncertainty (MU). Consequently, each measurement of plasma glucose concentration used for diagnosis and monitoring of diabetes mellitus (DM) is affected. Although concepts and methods of MU are well established in many fields of science and technology, they are presently only incompletely implemented by medical laboratories, neglecting MU of target values of internal quality control (IQC) materials.

Methods

An empirical and practical approach for the estimation of MU based on the analysis of routine IQC using control samples with assigned target values is presented. Its feasibility is demonstrated exemplarily by analyzing IQC data from one year obtained for glucose employing the hexokinase method with IQC of two different

SUBMITTER: Petersmann A 

PROVIDER: S-EPMC8875054 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature