Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies.

ABSTRACT: Many extensible tissues such as skin, lungs, and blood vessels require elasticity to function properly. The recoil of elastic energy stored during a stretching phase is provided by elastic fibers, which are mostly composed of elastin and fibrillin-rich microfibrils. In arteries, the lack of elastic fibers leads to a weakening of the vessel wall with an increased risk to develop cardiovascular defects such as stenosis, aneurysms, and dissections. The development of new therapeutic molecules involves preliminary tests in animal models that recapitulate the disease and whose response to drugs should be as close as possible to that of humans. Due to its superior in vivo imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model or

SUBMITTER: Hoareau M 

PROVIDER: S-EPMC8875079 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature