Diffusion- and Chemometric-Based Separation of Complex Electrochemical Signals That Originated from Multiple Redox-Active Molecules.

ABSTRACT: In situ analysis of multiple biomarkers in the body provides better diagnosis and enables personalized health management. Since many of these biomarkers are redox-active, electrochemical sensors have shown promising analytical capabilities to measure multiple redox-active molecules. However, the analytical performance of electrochemical sensors rapidly decreases in the presence of multicomponent biofluids due to their limited ability to separate overlapping electrochemical signals generated by multiple molecules. Here we report a novel approach to use charged chitosan-modified electrodes to alter the diffusion of ascorbic acid, clozapine, L-homocysteine, and uric acid-test molecules with various molecular charges and molecular weights. Moreover, we present a complementary approach to use c

SUBMITTER: Biton Hayun S 

PROVIDER: S-EPMC8875081 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature