Generation and Characterization of a Zebrafish IL-2Rγc SCID Model.
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ABSTRACT:
SUBMITTER: Sertori R
PROVIDER: S-EPMC8875600 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Generation and Characterization of a Zebrafish IL-2Rγc SCID Model.
Sertori Robert R Jones Realla R Basheer Faiza F Rivera Leni L Dawson Samantha S Loke Stella S Heidary Somayyeh S Dhillon Amardeep A Liongue Clifford C Ward Alister C AC
International journal of molecular sciences 20220221 4
The IL-2 family of cytokines act via receptor complexes that share the interleukin-2 receptor gamma common (IL-2Rγc) chain to play key roles in lymphopoiesis. Inactivating IL-2Rγc mutations results in severe combined immunodeficiency (SCID) in humans and other species. This study sought to generate an equivalent zebrafish SCID model. The zebrafish <i>il2rga</i> gene was targeted for genome editing using TALENs and presumed loss-of-function alleles analyzed with respect to immune cell development ...[more]
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