SWAAT Bioinformatics Workflow for Protein Structure-Based Annotation of ADME Gene Variants.

ABSTRACT: Recent genomic studies have revealed the critical impact of genetic diversity within small population groups in determining the way individuals respond to drugs. One of the biggest challenges is to accurately predict the effect of single nucleotide variants and to get the relevant information that allows for a better functional interpretation of genetic data. Different conformational scenarios upon the changing in amino acid sequences of pharmacologically important proteins might impact their stability and plasticity, which in turn might alter the interaction with the drug. Current sequence-based annotation methods have limited power to access this type of information. Motivated by these calls, we have developed the Structural Workflow for Annotating ADME Targets (SWAAT) that allows for th

SUBMITTER: Othman H 

PROVIDER: S-EPMC8875676 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature