P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models.

ABSTRACT: The superfamily of P-loop channels includes potassium, sodium, and calcium channels, as well as TRP channels and ionotropic glutamate receptors. A rapidly increasing number of crystal and cryo-EM structures have revealed conserved and variable elements of the channel structures. Intriguing differences are seen in transmembrane helices of channels, which may include π-helical bulges. The bulges reorient residues in the helices and thus strongly affect their intersegment contacts and patterns of ligand-sensing residues. Comparison of the experimental structures suggests that some π-bulges are dynamic: they may appear and disappear upon channel gating and ligand binding. The AlphaFold2 models represent a recent breakthrough in the computational prediction of protein structures. We compared so

SUBMITTER: Tikhonov DB 

PROVIDER: S-EPMC8876033 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature