Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases.

ABSTRACT:

Background

Multiple system atrophy (MSA) associated with neuroleptic malignant-like syndrome (NMLS) is rare and few cases have been described in the literature.

Case presentation

In the present study, three patients with MSA associated with NMLS were analyzed from January 2012 to January 2020 to characterize their clinical presentations. Data collected from the patients for analysis included general patient history, the fluctuation and severity of disease symptoms, the indicated therapies and disease progression at follow-up. All patients had histories of sudden withdrawal or reduction of levodopa prior to the onset of symptoms. Clinical presentations were characterized by hyperthermia, autonomic dysfunction, worsening of extrapyramidal symptoms, and elevated serum creatine

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8876065 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature