Controlled human exposure to diesel exhaust: a method for understanding health effects of traffic-related air pollution.

ABSTRACT: Diesel exhaust (DE) is a major component of air pollution in urban centers. Controlled human exposure (CHE) experiments are commonly used to investigate the acute effects of DE inhalation specifically and also as a paradigm for investigating responses to traffic-related air pollution (TRAP) more generally. Given the critical role this model plays in our understanding of TRAP's health effects mechanistically and in support of associated policy and regulation, we review the methodology of CHE to DE (CHE-DE) in detail to distill critical elements so that the results of these studies can be understood in context. From 104 eligible publications, we identified 79 CHE-DE studies and extracted information on DE generation, exposure session characteristics, pollutant and particulate composition of

SUBMITTER: Long E 

PROVIDER: S-EPMC8876178 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature