Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration.

ABSTRACT:

Background

A considerable number of studies has been carried out to develop alloplastic bone graft materials such as hydroxyapatite (HAP) that mimic the hierarchical structure of natural bones with multiple levels of pores: macro-, micro-, and nanopores. Although nanopores are known to play many essential roles in natural bones, only a few studies have focused on HAPs containing them; none of those studies investigated the functions of nanopores in biological systems.

Method

We developed a simple yet powerful method to introduce nanopores into alloplastic HAP bone graft materials in large quantities by simply pressing HAP nanoparticles and sintering them at a low temperature.

Results

The size of nanopores in HAP scaffolds can be controlled between 16.5 and 30.2 nm by

SUBMITTER: Kim C 

PROVIDER: S-EPMC8876184 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature