Molecular Pathological Diagnosis of Thyroid Tumors Using Spatially Resolved Metabolomics.

ABSTRACT: The pathological diagnosis of benign and malignant follicular thyroid tumors remains a major challenge using the current histopathological technique. To improve diagnosis accuracy, spatially resolved metabolomics analysis based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) technique was used to establish a molecular diagnostic strategy for discriminating four pathological types of thyroid tumor. Without any specific labels, numerous metabolite features with their spatial distribution information can be acquired by AFADESI-MSI. The underlying metabolic heterogeneity can be visualized in line with the cellular heterogeneity in native tumor tissue. Through micro-regional feature extraction and in situ metabolomics analysis, three sets of metab

SUBMITTER: Huang L 

PROVIDER: S-EPMC8876246 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature