Thermostable Vaccines in Veterinary Medicine: State of the Art and Opportunities to Be Seized.

ABSTRACT: The COVID-19 pandemic has highlighted the weakness of the vaccine supply chain, and the lack of thermostable formulations is one of its major limitations. This study presents evidence from peer-reviewed literature on the development of thermostable vaccines for veterinary use. A systematic review and meta-analysis were performed to evaluate the immunogenicity and/or the efficacy/effectiveness of thermostable vaccines against infectious diseases. The selected studies (n = 78) assessed the vaccine's heat stability under different temperature conditions and over different periods. Only one study assessed the exposure of the vaccine to freezing temperatures. Two field studies provided robust evidence on the immunogenicity of commercial vaccines stored at temperatures far in excess of the manuf

SUBMITTER: Fanelli A 

PROVIDER: S-EPMC8876287 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature