Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia.

ABSTRACT: Myocardial infarction causes pathological changes in the autonomic nervous system, which exacerbate heart failure and predispose to fatal ventricular arrhythmias and sudden death. These changes are characterized by sympathetic activation and parasympathetic dysfunction (reduced vagal tone). Reasons for the central vagal withdrawal and, specifically, whether myocardial infarction causes changes in cardiac vagal afferent neurotransmission that then affect efferent tone, remain unknown. The objective of this study was to evaluate whether myocardial infarction causes changes in vagal neuronal afferent signaling. Using in vivo neural recordings from the inferior vagal (nodose) ganglia and immunohistochemical analyses, structural and functional alterations in vagal sensory neurons were character

SUBMITTER: Salavatian S 

PROVIDER: S-EPMC8876456 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature