Ontology highlight
ABSTRACT:
SUBMITTER: Wan T
PROVIDER: S-EPMC8876573 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Wan Tao T Horová Magdaléna M Beltran Daisy Guiza DG Li Shanren S Wong Huey-Xian HX Zhang Li-Mei LM
Molecular cell 20210624 14
WhiB7 represents a distinct subclass of transcription factors in the WhiB-Like (Wbl) family, a unique group of iron-sulfur (4Fe-4S] cluster-containing proteins exclusive to the phylum of Actinobacteria. In Mycobacterium tuberculosis (Mtb), WhiB7 interacts with domain 4 of the primary sigma factor (σ<sup>A</sup><sub>4</sub>) in the RNA polymerase holoenzyme and activates genes involved in multiple drug resistance and redox homeostasis. Here, we report crystal structures of the WhiB7:σ<sup>A</sup> ...[more]