The effect of age on ventilation management and clinical outcomes in critically ill COVID-19 patients--insights from the PRoVENT-COVID study.

ABSTRACT:

Introduction

We analyzed the association of age with ventilation practice and outcomes in critically ill COVID-19 patients requiring invasive ventilation.

Methods

Posthoc analysis of the PRoVENT-COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end-expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital- and ICU stay, and mortality.

Results

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SUBMITTER: Hol L 

PROVIDER: S-EPMC8876900 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature