Therapeutic Efficacy of 177Lu-Labeled A20FMDV2 Peptides Targeting ανβ6.

ABSTRACT: Integrin ανβ6 promotes migration and invasion of cancer cells, and its overexpression often correlates with poor survival. Therefore, targeting ανβ6 with radioactive peptides would be beneficial for cancer imaging and therapy. Previous studies have successfully developed radiotracers based on the peptide A20FMDV2 that showed good binding specificity for ανβ6. However, one concern of these ανβ6 integrin-targeting probes is that their rapid blood clearance and low tumor uptake would preclude them from being used for therapeutic purposes. In this study, albumin binders were used to increase tumor uptake for therapeutic applications while the non-albumin peptide was evaluated as a potential positron emission tomography (PET) imaging agent. All peptides used the DOTA chelator for radiolabeling

SUBMITTER: Huynh TT 

PROVIDER: S-EPMC8876964 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature