Cellular Uptake of Silica and Gold Nanoparticles Induces Early Activation of Nuclear Receptor NR4A1.

ABSTRACT: The approval of new nanomedicines requires a deeper understanding of the interaction between cells and nanoparticles (NPs). Silica (SiO2) and gold (Au) NPs have shown great potential in biomedical applications, such as the delivery of therapeutic agents, diagnostics, and biosensors. NP-cell interaction and internalization can trigger several cellular responses, including gene expression regulation. The identification of differentially expressed genes in response to NP uptake contributes to a better understanding of the cellular processes involved, including potential side effects. We investigated gene regulation in human macrophages and lung epithelial cells after acute exposure to spherical 60 nm SiO2 NPs. SiO2 NPs uptake did not considerably affect gene expression in epithelial cells, wh

SUBMITTER: Sousa de Almeida M 

PROVIDER: S-EPMC8877036 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature