Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models.

ABSTRACT: Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, al

SUBMITTER: Suther C 

PROVIDER: S-EPMC8877038 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature